After the Fallout 4 trailer came out today, there has been an enormous amount of excitement about the game.  During careful review of the newly released trailer of the game, it does indeed appear that the game will be set in Boston, Massachusetts.

According to historical fiction author, Sophie Turner, the image of the ship with rocket boosters on it does appear to be the USS Constitution, which typically has docked in Boston in the past.  Also, an image of the Bunker Hill monument, the Paul Revere statue, and the Old North Church are visible as well.

Fallout_Ship
A screenshot of what appears to be the USS Constitution with retro rockets on it
Paul_Revere_Statue
This monument of Paul Revere has a Steam Punk-type dirigible in the background.
The Bunker Hill monument looks to be dilapidated from nuclear war.